Research Articles
Orthogonal Methods for Screening Hit Validation: A Strategic Guide for Robust Drug Discovery
This article provides a comprehensive guide for researchers and drug development professionals on implementing orthogonal methods to validate screening hits.
Functional Genomics Screening Strategies in 2025: A Comparative Guide for Drug Discovery and Biomedical Research
This article provides a comprehensive comparison of modern functional genomics screening strategies, tailored for researchers and drug development professionals.
A Comprehensive Guide to Benchmarking Differential Gene Expression Tools: From Foundational Principles to Clinical Applications
This comprehensive review synthesizes current methodologies and best practices for benchmarking differential gene expression (DGE) analysis tools across diverse transcriptomic data types.
Functional Validation of Genetic Variants: A Comprehensive Guide from Foundational Concepts to Clinical Protocols
This article provides researchers, scientists, and drug development professionals with a comprehensive framework for the functional validation of genetic variants.
CRISPR vs RNAi: A Comprehensive Comparison of Efficiency, Applications, and Best Practices for Genetic Research
This article provides a detailed comparison of CRISPR and RNA interference (RNAi) technologies for genetic perturbation, tailored for researchers, scientists, and drug development professionals.
Overcoming Low sgRNA Efficiency: A Strategic Guide for Optimizing CRISPR Library Performance
Low sgRNA efficiency remains a significant bottleneck in CRISPR/Cas9 screens, impacting the signal-to-noise ratio and reliability of genetic screens.
A Standardized CRISPR Screening Workflow: From Foundational Concepts to Clinical Translation
This article provides a comprehensive guide for standardizing CRISPR screening workflows, addressing the critical needs of researchers, scientists, and drug development professionals.
Batch Effect Correction in Genomic Data: A Comprehensive Guide for Robust Biomedical Research
This article provides a comprehensive guide for researchers and drug development professionals on addressing the pervasive challenge of batch effects in genomic data analysis.
Strategies for Managing False Positives in Screening Data: From Drug Discovery to Clinical Trials
This article provides a comprehensive guide for researchers, scientists, and drug development professionals on addressing the pervasive challenge of false positives in scientific screening.
Troubleshooting NGS Data Quality: A Comprehensive Guide from QC to Clinical Standards
This guide provides researchers, scientists, and drug development professionals with a systematic framework for identifying, troubleshooting, and resolving next-generation sequencing (NGS) data quality issues.