Research Articles
Unraveling Biology and Disease with CRISPR Screens in Organoids and Stem Cells: A 2024 Guide
This article provides a comprehensive guide to performing and interpreting CRISPR-based screens in complex stem cell-derived organoid models.
CRISPR Screen Replicate Correlation Analysis: A Comprehensive Guide to Ensuring Data Quality and Biological Reproducibility
This article provides a complete framework for analyzing and interpreting replicate correlation in CRISPR screening experiments, essential for researchers in functional genomics and drug discovery.
Why Is My CRISPR Screen Low? A Troubleshooting Guide to Fixing Poor sgRNA Mapping Rates in 2024
This article provides a comprehensive, step-by-step guide for researchers encountering low sgRNA mapping rates in CRISPR knockout or perturbation screens.
CRISPR Screen Low Mapping Rate: Causes, Troubleshooting, and Solutions for Genetic Researchers
This comprehensive guide addresses the common yet critical challenge of low mapping rates in CRISPR screening experiments.
Decoding CRISPR Screens: A Comprehensive Guide to Interpreting Log-Fold Change Data for Research and Drug Discovery
This article provides a definitive guide for scientists and drug development professionals on interpreting log-fold change (LFC) data from CRISPR knockout and activation screens.
Unlocking Resistance: How CRISPR Screens Are Revolutionizing Immune Checkpoint Inhibitor Research
This article provides a comprehensive guide for researchers and drug development professionals on leveraging CRISPR screening to advance immune checkpoint inhibitor (ICI) therapies.
CRISPR Screening for Drug Target Discovery: A Comprehensive Guide for Research Scientists
This article provides a detailed roadmap for researchers and drug development professionals on utilizing CRISPR screening to identify novel therapeutic targets.
CRISPR Screen Data Normalization: Essential Methods for Robust Analysis in 2024
This comprehensive guide explores the critical role of data normalization in CRISPR screen analysis.
CRISPR Nickase Strategy: Paired Nicking for Precision Genome Editing and Therapeutic Development
This article provides a comprehensive guide to the CRISPR nickase strategy for paired nicking, a pivotal technique for enhancing the precision and safety of genome editing.
Precision and Recall in CRISPR Screens: The Essential Guide to Performance Metrics and Hit Validation
This comprehensive guide explores the critical role of precision-recall analysis in evaluating CRISPR library screening performance.