Research Articles
Mastering ALDEx2: A Comprehensive Guide to Log-Ratio Analysis for Robust Differential Expression in RNA-Seq
This protocol provides a complete, step-by-step guide to performing robust differential abundance analysis using ALDEx2's log-ratio transformation for RNA-seq data.
Mastering ACMG/AMP PS3/BS3 Criteria: A Comprehensive Guide to Functional Evidence in Clinical Genomics
This article provides a detailed, practical guide for researchers, scientists, and drug development professionals on applying the critical ACMG/AMP PS3 (supporting pathogenic) and BS3 (supporting benign) criteria for functional evidence...
AAV vs Lentiviral Vectors for In Vivo Screening: Choosing the Right Tool for Functional Genomics and Drug Discovery
This article provides a comprehensive guide for researchers on selecting and implementing viral vectors for in vivo genetic screening.
Single-Cell Showdown: 10x Genomics vs. Parse Biosciences — Which Platform Delivers Superior Performance for Your Research?
This comprehensive comparison provides researchers, scientists, and drug development professionals with a detailed analysis of 10x Genomics and Parse Biosciences single-cell sequencing platforms.
Mastering Single-Cell RNA-seq: A Complete Guide to the 10x Genomics Chromium Protocol
This comprehensive guide provides researchers and drug development professionals with an in-depth exploration of the 10x Genomics Chromium single-cell RNA sequencing (scRNA-seq) platform.
Benchmarking Functional Genomics Computational Tools: A Guide to Methods, Applications, and Best Practices
This article provides a comprehensive guide for researchers and drug development professionals on benchmarking computational tools in functional genomics.
Functional Validation of Genetic Variants: From VUS to Pathogenicity in Biomedical Research
This article provides a comprehensive guide to the functional validation of genetic variants for researchers and drug development professionals.
Evaluating Sensitivity and Specificity in Functional Assays: A Comprehensive Guide for Robust Research and Development
This article provides researchers, scientists, and drug development professionals with a comprehensive framework for evaluating the sensitivity and specificity of functional assays.
Comparative Functional Genomics Study Design: Principles, Methods, and Best Practices for Biomedical Research
This article provides a comprehensive guide to designing effective comparative functional genomics studies, tailored for researchers and drug development professionals.
EPSCs vs ESCs: A Comparative Functional Genomics Guide to Molecular Features and Therapeutic Potential
This article provides a comprehensive comparison of Expanded Potential Stem Cells (EPSCs) and Embryonic Stem Cells (ESCs) for researchers and drug development professionals.