Research Articles
Unlocking Genetic Mysteries: How Transcriptome Sequencing Revolutionizes Diagnosis of Mendelian Disorders
Explore how transcriptome sequencing is transforming the diagnosis of Mendelian disorders, increasing diagnostic rates and bringing hope to millions affected by rare genetic conditions.
The Invisible Flock: How Germ-Free Chicks Revealed the Secret World of the Chicken Gut
Discover how germ-free chickens are helping scientists understand the complex microbiome that plays a vital role in poultry health and global food security.
The Unseen Key: How a Hidden Byproduct of a Common Drug Triggers a Dangerous Reaction
Discover how carbamazepine's metabolite CBZ-10,11-epoxide triggers severe immune reactions in genetically susceptible individuals through peptide alteration.
The Hidden Blueprint: How a New Dog Genome is Rewriting the Textbook
A new high-resolution dog genome is revealing thousands of previously hidden functional elements, filling gaps in our understanding of canine genetics and health.
Genome Cartography: Navigating the Ever-Evolving Map of Life
Discover how a clever 'flip and compare' strategy using weighted sequence alignment is revolutionizing genetic research and genome annotation lift over.
Supercharging a Microbial Workhorse: How Corynebacterium glutamicum Brews Your Lysine
Explore how metabolic engineering transforms Corynebacterium glutamicum into an efficient L-lysine production factory with advanced cellular optimization techniques.
Unlocking the Genetic Dimmer Switch: The Story of the Chicken miR-17-92 Cluster
Discover how scientists uncovered the regulatory mysteries of the chicken miR-17-92 cluster, a crucial genetic switch controlling development and disease.
The Invisible Switch: How FANCF Gene Silencing Fuels Lung Cancer
Explore how FANCF gene promoter hypermethylation disrupts DNA repair mechanisms and drives non-small cell lung cancer development through epigenetic silencing.
The Nuclear Gateway Hypothesis: How Misshapen Brain Cell Nuclei Drive Neurodegeneration
Discover how tau-induced nuclear envelope invagination causes toxic mRNA accumulation in Drosophila, revealing new insights into Alzheimer's disease mechanisms.
The Evolutionary Arms Race: How MHC Class I Genes Shaped Immune Systems from Sharks to Humans
Explore the fascinating evolution of MHC class I molecules across vertebrates and their crucial role in immune system function from sharks to humans.